Take our user survey and make your voice heard.
Image: GeorgeSe/iStock
health

Drugs that aren’t antibiotics can also kill bacteria − new method pinpoints how

8 Comments
By Mariana Noto Guillen

The requested article has expired, and is no longer available. Any related articles, and user comments are shown below.

© The Conversation

©2024 GPlusMedia Inc.

8 Comments
Login to comment

There is hope in these drugs as a way to support antibiotics or (if everything goes well) even replace some varieties of them. After all it is rational to expect drugs that cause a variety of effect on the human cells to also affect bacteria, after all traditional antibiotics do the same in the opposite sense.

Then again, it is very different to prove an effect on a computer simulation or in cell cultures than to do the same in a living organism. But even if none of the current drugs being studied proves to have a practical use as an antibiotic the research can still lead to discovering new drugs that could.

-4 ( +1 / -5 )

Plain soap and water do wonders to prevent surgical infections and sepsis. The increase in lifespans in the decades prior to the advent of antibiotics was in no small part due to the adoption of soap and water in surgeries, and in every day life. The other major contributor to increased life spans was the adoption of the practice of vaccinations against preventable diseases.

-3 ( +0 / -3 )

Interesting, now they are testing the potential benefits of nonantiboitic drugs for bacteria infections that are used for parasite infections. So, nonantibiotic parasitic medications like triclabendazole and I'm guessing Ivermectin which is in the same class of anti-parasitic medications. Remember just a short while ago, Ivermectin (which is a FDA-approved human medication) was labeled as horse/animal medications from the media. Interesting how quickly things have changed. The change of narratives is on which medications they are heavily marketing. However, that is great if the nonantibiotics is a breakthrough and does have benefits in combatting bacteria infections.

1 ( +2 / -1 )

Interesting how quickly things have changed

Nothing has change about ivermectin, it has been demonstrated beyond any reasonable doubt to be worthless against covid, and likely for any viral infection that shares the same mechanisms.

No change of narratives, no change on indications, not even any mention of ivermectin in the article, the one antiparasitic mentioned is triclabendazole that acts inhibiting microtubule formation and adenylate cyclase activity, meanwhile ivermectin act on chloride channels on the membrane of the muscle cells of the parasites paralyzing them, just because drugs are categorized together according to their ability to kill parasites that does not mean they have the same mechanism of action, as in this case they can be completely different.

-2 ( +1 / -3 )

@virusrex

Nothing has change about ivermectin, it has been demonstrated beyond any reasonable doubt to be worthless against covid, and likely for any viral infection that shares the same mechanisms.

No change of narratives, no change on indications, not even any mention of ivermectin in the article, the one antiparasitic mentioned is triclabendazole that acts inhibiting microtubule formation and adenylate cyclase activity, meanwhile ivermectin act on chloride channels on the membrane of the muscle cells of the parasites paralyzing them, just because drugs are categorized together according to their ability to kill parasites that does not mean they have the same mechanism of action, as in this case they can be completely different.

I never said anything about covid. I just said that Ivermectin is not horse medication like the media and big pharma were pushing. However, there have been many studies that have shown ivermectin to lower the viral load for people infected with covid. It has it not been completely proven effective against covid, however, it also has not been proven beyond a reasonable doubt that ivermectin is not effective against covid. You are jumping to conclusions way too quickly without letting further research investigate.

I mentioned ivermectin because it is in the same class of medication as triclabendazole and many times ivermectin is used in combination with triclabendazole as an anti-parasitic. They both have the same function effective againse parasites. Satoshi Ōmura and William C. Campbell (inventors of ivermectin) got a nobel peace prize for it in 2015 and it is not just some horse medication.

-1 ( +2 / -3 )

I never said anything about covid. I just said that Ivermectin is not horse medication like the media and big pharma were pushing.

Again, nothing has changed about ivermectin, it is used for the same things it was used before, absolutely nothing in this article indicates things have changed. Not even for the drugs being investigated because there is a huge difference between something having an effect in vitro and that something ending up being clinically significant on patients.

However, there have been many studies that have shown ivermectin to lower the viral load for people infected with covid. 

Not to any degree that would have importance, which is why the current understanding is that is worthless for covid patients, even worse it brinks toxic risks specially for the patients that are vulnerable so it is worse than not using anything.

You are jumping to conclusions way too quickly without letting further research investigate.

It is not me who concluded ivermectin is worthless but the scientific consensus, no institution of medical science disagrees with the conclusion that the drug should not be used for covid, none. They have done enough research to prove beyond any reasonable doubt this, it is not believable you did a better job than all the scientists of the planet evaluating the evidence.

https://www.medscape.com/viewarticle/982852

Most randomized trials showed no effect of the drug. A couple of larger trials which seemed to show dramatic effects were subsequently shown to be fraudulent.

I mentioned ivermectin because it is in the same class of medication as triclabendazole

Again, no it is not, chloride channel inhibitors are not the same class as microtubule formation inhibitors, they are nowhere near being the same thing, that would be like saying wound dressings and vitamin K are in the same "class" just because both can be used to stop bleeding, they do not have the same function at all, as easily proved as they are not interchangeable.

Satoshi Ōmura and William C. Campbell (inventors of ivermectin) got a nobel peace prize for it in 2015 and it is not just some horse medication.

In countries like the US that is still the main use it has, because that is where it is effective. The nobel prize was not about any effect beyond what is actually useful for, which has nothing to do with bacterial nor viral infections.

-1 ( +1 / -2 )

But if nonantibiotics kill bacteria in similar ways to known antibiotics...

then they would be antibiotics, right?

I guess they call them "nonantibiotics" simply because they haven't been approved as antibiotics yet....

However, there have been many studies that have shown ivermectin to lower the viral load for people infected with covid. 

Not to any degree that would have importance, which is why the current understanding is that is worthless for covid patients, even worse it brinks toxic risks specially for the patients that are vulnerable so it is worse than not using anything.

It is infinitely safer and at least as effective as the new expensive drugs that received EUAs....

0 ( +1 / -1 )

then they would be antibiotics, right?

The whole point is that the drugs are not considered nor used as antibiotics but may have antibiotic properties. It is not as simple as being approved or not, but that a clinical effect can be observed, a likely scenario is that the mechanism of action for their antibacterial property becomes better understood and new drugs are designed to exploit that mechanism effectively.

It is infinitely safer and at least as effective as the new expensive drugs that received EUAs....

That is not true, ivermectin has been definitely demonstrated as useless against covid, and it has well known toxic effects that are specially dangerous precisely for the patients for whom it would be necessary.

-2 ( +0 / -2 )

Login to leave a comment

Facebook users

Use your Facebook account to login or register with JapanToday. By doing so, you will also receive an email inviting you to receive our news alerts.

Facebook Connect

Login with your JapanToday account

User registration

Articles, Offers & Useful Resources

A mix of what's trending on our other sites