Nurse Kathe Olmstead, right, gives volunteer Melissa Harting, of Harpersville, N.Y., an injection as the world's biggest study of a possible COVID-19 vaccine, developed by the National Institutes of Health and Moderna Inc., gets underway Monday, July 27, 2020, in Binghamton, N.Y. (AP Photo/Hans Pennink)
health

Experimental COVID-19 vaccine is put to its biggest test

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By LAURAN NEERGAARD, MICHAEL HILL and JOCELYN NOVECK

The biggest test yet of an experimental COVID-19 vaccine got underway Monday with the first of some 30,000 Americans rolling up their sleeves to receive shots created by the U.S. government as part of the all-out global race to stop the outbreak.

The glimmer of hope came even as Google, in one of the gloomiest assessments of the coronavirus's staying power from a major employer, decreed that most of its 200,000 employees and contractors should work from home through next June — a decision that could influence other big companies.

Final-stage testing of the vaccine, developed by the National Institutes of Health and Moderna Inc., began with volunteers at numerous sites around the U.S. given either a real dose or a dummy without being told which.

“I’m excited to be part of something like this. This is huge,” said Melissa Harting, a 36-year-old nurse who received an injection in Binghamton, New York. Especially with family members in front-line jobs that could expose them to the virus, she added, “doing our part to eradicate it is very important to me.”

It will be months before results trickle in, and there is no guarantee the vaccine will ultimately work against the scourge that has killed about 650,000 people around the world, including almost 150,000 in the U.S.

“We’ve been sitting on the sidelines passively attempting to wear our masks and social distance and not go out when it’s not necessary. This is the first step of becoming active against this,” said Dr. Frank Eder of Meridian Clinical Research, the company that runs the Binghamton trial site. “There’s really no other way to get past this.”

As if to underline how high the stakes are, there were more setbacks in efforts to contain the coronavirus.

In Washington, the Trump administration disclosed that national security adviser Robert O’Brien has the virus — the highest-ranking U.S. official to test positive so far. The White House said he has mild symptoms and “has been self-isolating and working from a secure location off site.”

The move to restart the national pastime ran into trouble just five days into the long-delayed season: Two major league baseball games scheduled for Monday night were called off as the Miami Marlins coped with an outbreak — the Marlins’ home opener against the Baltimore Orioles, and the New York Yankees’ game in Philadelphia, where the Marlins used the clubhouse over the weekend.

As for relief from the economic damage done by the virus, Republicans on Capitol Hill planned to roll out a $1 trillion package that could include a new round of $1,200 stimulus checks but reduce the extra $600 a week in federal unemployment benefits that are expiring for millions of Americans this week.

In Europe, rising infections in Spain and other countries caused alarm only weeks after nations reopened their borders in hopes of reviving tourism. Over the weekend, Britain imposed a 14-day quarantine on travelers arriving from Spain, Norway ordered a 10-day quarantine for people returning from the entire Iberian peninsula, and France urged its citizens not to visit Spain’s Catalonia region.

Scientists set speed records getting a made-from-scratch vaccine into massive testing just months after the coronavirus emerged. But they stressed that the public shouldn’t fear that anyone is cutting corners.

“This is a significant milestone,” NIH Director Francis Collins said after the very first test injection was given, at 6:45 a.m. in Savannah, Georgia. “Yes, we’re going fast, but no, we are not going to compromise” on proving whether the vaccine is safe and effective.

“We are focusing on speed because every day matters,” added Stephane Bancel, CEO of Massachusetts-based Moderna.

After volunteers get two doses a month apart, scientists will closely track which group experiences more infections as they go about their daily routines, especially in areas where the virus is spreading unchecked.

The answer probably won’t come until November or December, cautioned Dr. Anthony Fauci, NIH’s infectious-diseases chief.

Among many questions the study may answer: How much protection does just one dose offer compared with the two scientists think are needed? If it works, will it protect against severe disease or block infection entirely?

Don’t expect a vaccine as strong as the measles vaccine, which prevents about 97% of measles infections, Fauci said, adding he would be happy with a COVID-19 vaccine that’s 60% effective.

Several other vaccines made by China and by Britain’s Oxford University began smaller final-stage tests in Brazil and other hard-hit countries earlier this month. But the U.S. requires its own tests of any vaccine that might be used in the country.

Every month through the fall, the government-funded COVID-19 Prevention Network will roll out a new study of a leading candidate, each with 30,000 volunteers.

The final U.S. study of the Oxford shot is set to begin in August, followed by a candidate from Johnson & Johnson in September and one from Novavax in October. Pfizer Inc. plans its own 30,000-person study this summer.

That’s a stunning number of people needed to roll up their sleeves for science. In recent weeks, more than 150,000 Americans filled out an online registry signaling interest, Collins said. But many more are needed.

NIH is working to make sure that the study isn’t just filled with healthy, younger volunteers but includes populations hit hardest by COVID-19, including older adults, those in poor health and African-Americans and Latinos.

“We really are going to depend upon that sense of volunteerism for individuals from every different corner of society if we’re going to really find out how this vaccine, and its potential to end this terrible pandemic, is go to work in each of those groups,” Collins said.

© Copyright 2020 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.

©2020 GPlusMedia Inc.


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All the different news about vaccine makes me confused.

Are we getting some soon, or will it take a few more years or will get never a vaccine?

The many different news are so confusing....

3 ( +4 / -1 )

@Monty

There are a lot of different vaccines being developed. Even with positive preliminary results most of them are expected to fail in the end because of a number of reasons, for example protection not lasting for too long, protection not generated depending on age, possible side effects etc. If we're lucky out of the 100+ vaccines being developed a couple might provide lasting protection. In order to make sure that vaccines are safe a number of trials need to be conducted, starting from small and increasing the number of people tested at every stage. Each stage of these trials takes a few months to conclude. If one of the vaccines that are on the final stage mentioned in the article prove to be safe and provide lasting protection it still needs to be approved and mass produced in the millions. That's why even if we're lucky the soonest the vaccine can start circulating is around spring-summer 2021...

3 ( +3 / -0 )

It's encouraging that trials have started on a potential Covid-19 vaccine.

Ironic that these particular trials are taking place in a country where, according to polls, anywhere up to 50% of the population say they won't be availing themselves of it.

4 ( +4 / -0 )

new round of $1,200 stimulus checks

Still waiting for the last round of checks here. Nobody I've asked had received it either.

Read elsewhere they are hoping for 50% effectiveness. That's like a 50% accurate pregnancy test. Good new! If you are a man, you aren't pregnant. Way to take the guesswork out.

Hopefully, your family isn't in the 50% where the vaccine fails.

I'll get vaccinated at some point, but the effectivity will matter in the choice for when. I'm a huge believer in vaccines, effective vaccines. Was looking over my vaccine records just yesterday to see it is time for some 10yr boosters and my yellow fever cert has expired. Here, the Yellow Fvr is expensive, so I only get that when planning a trip to specific parts of the world.

Most routine childhood vaccines are effective for 85% to 95% of recipients.

https://www.who.int/vaccine_safety/initiative/detection/immunization_misconceptions/en/index2.html

0 ( +1 / -1 )

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