health

Sleep problems linked to heart health risks during and after menopause

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By Laura Williamson, American Heart Association News

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While we eagerly await publication of the findings of this study, and tangible benefits with adequate sleep during and after menopause, there is another study that surfaced about a week ago, that can affect many non-menopausal women.

As reported in the BMJ (https://bmjopen.bmj.com/content/13/12/e073592), the more sedentary leisure time that women spend, the greater their overall risk of developing uterine fibroids seemed to be.

Uterine fibroids, being a benign womb growth that often doesn’t produce any symptoms at all, but all-too-often results in excessive bleeding, pelvic and abdominal pain, and (infrequently) infertility, seems to rise in tandem with the amount of time spent sitting or lying down during the day. The authors do caution that this is an observational study, so it wasn’t intended to establish a cause-and-effect. And did not take into account obesity or other possible intersecting risk factors that the women faced during the study. Still, though, it provides enough correlation for women to considering consulting with their medical practitioner about exercise and everyday activity if fibroids become a concern.

-1 ( +0 / -1 )

People are asking too many questions about the recent rise in unexplained cardiac problems in otherwise healthy individuals.

No they are not, mostly because these "recent rise of unexplained cardiac problems" are just a false claim made by antiscientific propaganda groups that have been completely debunked by evidence.

For example:

https://www.ahajournals.org/doi/epdf/10.1161/CIRCULATIONAHA.123.065908

*The overall incidence of sudden cardiac death (SCD) among National Collegiate Athletic Association athletes has decreased over the past 20 years.*

-2 ( +2 / -4 )

Male menopause is tough too.

3 ( +3 / -0 )

Seems that the media is always pointing to potential causes of heart trouble.

That's a fact.

People are asking too many questions about the recent rise in unexplained cardiac problems in otherwise healthy individuals.

They all share a common characteristic too.

0 ( +2 / -2 )

They all share a common characteristic too.

That is still completely false, mostly because these "recent rise of unexplained cardiac problems" are just a false claim made by antiscientific propaganda groups that have been completely debunked by evidence.

0 ( +1 / -1 )

virusrexDec. 9 05:39 pm JST

With all due respect, and in long overdue recognition over your long struggles, within these four walls, to combat instances of obvious misinformation, I nevertheless urge you to review and consider two studies.

The first, released about six weeks ago, addresses a rare - but nevertheless clinically significant cases seen after vaccination with adenovirus-based vaccines that shows recipients making antibodies to PF4 (signals released by blood platelets relating to clotting).

PF4 (so the study tells us) being a "chemokine released from platelet α-granules upon activation," and is "central to the pathophysiology of vaccine-induced immune thrombocytopenia and thrombosis (VITT)" Well, the antibodies, in turn, latches onto PF4 and form 'clumps' that can bind to Fc receptors on other platelets.

The study (https://ashpublications.org/blood/article/doi/10.1182/blood.2023020872/498431/PF4-activates-the-c-Mpl-Jak2-pathway-in-platelets) indicates that PF4 alone also activates c-Mpl-Jak2 pathways in platelets, which will be an additional receptor that causes further platelet accumulation.

Specifically: "In this study, we show that PF4 binds and activates the thrombopoietin (TPO) receptor, c-Mpl on platelets. This leads to the activation of Janus kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5, leading to platelet aggregation. Inhibition of the c-Mpl-JAK2 pathway inhibits platelet aggregation to PF4, VITT serum, and to the combination of PF4 and IgG isolated from VITT patient plasma."

Again, this is an important read for practicing professionals. Much more work needs to be done in this area.

The second, without a clear doubt, you already know about. A little over a year ago. https://www.nejm.org/doi/full/10.1056/NEJMc2210813. Research that links "very rare cases of thrombosis with thrombocytopenia syndrome, later named vaccine-induced immune thrombocytopenia and thrombosis (VITT)" with adenovirus vector vaccines, such as Ad5-nCoV (CanSinoBio Biologics) and Gam-COVID-Vac (Sputnik V). The result of which the authors state that, for those around the globe (and their are many) who received the Sputnik V: "Because even a very low case rate could have resulted in hundreds of cases, it is mandatory to raise public awareness and to take the necessary steps to expand early detection of VITT after the administration of the Sputnik V vaccine."

The science is continuing to develop over all of this. Cheers!

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That is still completely false, mostly because these "recent rise of unexplained cardiac problems" are just a false claim made by antiscientific propaganda groups that have been completely debunked by evidence.

A purely irrelevant response that does not respond to the actual issue.

Again, this is an important read for practicing professionals.

Good point; we only see opinions here of those who are not in the industry.

-1 ( +3 / -4 )

With all due respect, and in long overdue recognition over your long struggles, within these four walls, to combat instances of obvious misinformation, I nevertheless urge you to review and consider two studies.

Both studies address a well known explanation for the increase, not as the original comment said "recent rise in unexplained cardiac problems" which is used by antivaxxer propaganda groups without any justification. This is a well explained risk and more specially it does not compare with the risk of not vaccinating in any population with active transmission of covid, that means vaccinated people have a lower risk of cardiac problems not an increase (comparaed with unvaccinated people) and specially not unexplained.

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A purely irrelevant response that does not respond to the actual issue.

There is no issue as described by the comment, that is what the response clearly proves, even with a reference. Demonstrating the problem described do not exist is a perfectly valid response.

The problem actually being described in the article is on the other hand real and important enough to require action.

Good point; we only see opinions here of those who are not in the industry.

What basis do you have to know if anybody else commenting is or not in the industry? without any evidence for all you know everybody else here could be in the industry.

-3 ( +1 / -4 )

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