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Japan set to approve Lilly's donanemab to treat Alzheimer's disease

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Drugs to slow cognitive decline are badly needed in Japan.

Hopefully, these drugs will be subsided by the government.

1 ( +3 / -2 )

Kyodo reporter's needed to have dived just a little deeper:

In the clinical trial, among people receiving donanemab, micro-bleeding occurred in 31.4% and brain swelling in 24%.

ARIA usually does not cause symptoms, the company said in a release, but it can be serious and life-threatening. In the trial, three people died from a serious case of ARIA.

https://www.healthline.com/health-news/fda-delays-approval-eli-lilly-alzheimers-drug#Is-donanemab-safe?

One has to wonder if regulatory approval in one of the world's most aged societies involved the exchange of thick brown envelopes.

2 ( +3 / -1 )

Alzheimer's can not only be prevented but reversed with a low-carb diet, B vitamins, fish oils and exercise.

I'm not a fan of treating the symptoms of anything with pharma products. Let's focus on the causes and prevention.

-2 ( +3 / -5 )

Alzheimer's can not only be prevented but reversed with a low-carb diet, B vitamins, fish oils and exercise.

Any links to respectable medical organizations saying this?

2 ( +4 / -2 )

StrangerlandToday 04:12 pm JST

Any links to respectable medical organizations saying this?

Research is conflicting on this, apparently due to most studies involving self-reporting of dietary habits. The National Institute on Aging in the US has an interesting article that includes this study,

In March 2023, scientists completed a study of the brains of about 600 older adults who died at an average age of 91. Brain autopsies found that people who had reported sticking to a Mediterranean or MIND diet showed less evidence of Alzheimer’s pathologies, including tau tangles and amyloid plaques.

What Do We Know About Diet and Prevention of Alzheimer’s Disease?

https://www.nia.nih.gov/health/alzheimers-and-dementia/what-do-we-know-about-diet-and-prevention-alzheimers-disease

1 ( +2 / -1 )

In March 2023, scientists completed a study of the brains of about 600 older adults who died at an average age of 91. Brain autopsies found that people who had reported sticking to a Mediterranean or MIND diet showed less evidence of Alzheimer’s pathologies, including tau tangles and amyloid plaques.

The above qutoe does not state this:

Alzheimer's can not only be prevented but reversed with a low-carb diet, B vitamins, fish oils and exercise.

And it sounds like the top quote is from a single study.

As I asked, are there any respectable medical organizations stating that Alzheimer's can not only be prevented but reversed with a low-carb diet, B vitamins, fish oils and exercise?

0 ( +2 / -2 )

Strangerland:

As I asked, are there any respectable medical organizations stating that Alzheimer's can not only be prevented but reversed with a low-carb diet, B vitamins, fish oils and exercise?

What constitutes as reputable? There is a lot on this. Also, get off industrial processed 'foods' for a start. Plenty of evidence that consuming these concoctions are an issue regarding the development of Alzheimer's.

0 ( +1 / -1 )

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