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AstraZeneca: Shot will be effective against COVID-19 variant

8 Comments
By SYLVIA HUI

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8 Comments
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And how about the side effects?

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“We think we have figured out the winning formula and how to get efficacy that, after two doses, is up there with everybody else,” Soriot said.

I would certainly hope you could get the efficacy up. I expect that it is unlikely I will be able to choose which vaccine I get but 70% does not sound like particularly good odds to me. 70% instead of 95% means nearly a third of people having this vaccine could still get sick from Covid-19 - If you cannot get it up, I want the Pfizer vaccine.

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If you cannot get it up, I want the Pfizer vaccine.

Interesting choice of words when you consider another well known Pfizer medication. But you do have a fair point.

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@Haaa Nemui.

LOL. Nice one

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According to WebMD:

https://www.webmd.com/vaccines/covid-19-vaccine/news/20201214/closer-look-at-three-covid-19-vaccines

AstraZeneca "has not submitted application for emergency use authorization in U.S.", so the side effects are "not yet known" (not yet announced)

"Safety data from nearly 24,000 people in four trials in the United Kingdom, Brazil and South Africa found that, over a median of 3.4 months, only three participants had serious side effects possibly related to the vaccine. All recovered or are recovering and remain in the trial, according to the findings published online Dec. 8 in **The Lancet."**

I would certainly hope you could get the efficacy up. I expect that it is unlikely I will be able to choose which vaccine I get but 70% does not sound like particularly good odds to me.

70% is the weighted average of 2 different doses - an error/stroke of luck that led to an interesting discovery:

https://www.healthline.com/health-news/what-to-know-about-the-astrazeneca-vaccine-controversy

"During the clinical trials, some participants were mistakenly given half a dose rather than a full dose in their first round of shots, according to BBC News. Still, the trial continued and the researchers discovered those given the weaker dosage produced a better immune response.

When regulators were informed of the mistake — that nearly 3,000 participants had received a lower dose — they permitted the trial to continue, as the dosing error had no impact on the vaccine’s safety.

In fact, the dosing mistake led to an interesting discovery.

In the participants who received two full doses, the vaccine efficacy was 62 percent. But in those who received a half dose and a full dose, efficacy was close to 90 percent.

“It’s a happy coincidence that they sort of stumbled onto a way that seems to be a better way for the human immune system to receive that particle vaccine, process it, and prepare for a longer-lasting immunity,” said Dr. Matthew Heinz, a hospitalist based in Tucson, Arizona, noting that the findings aren’t yet conclusive.

Averaged together, AstraZeneca announced via a press release its vaccine is 70 percent effective at preventing COVID-19.

The researchers are investigating why the weaker dose produced a more robust immune response."

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Better than infecting mass humans with monkey DNA. But in reality, not fully tested, in combination with Sputnik V, I would prefer for my elderly parents.

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And how about the side effects?

What side effects?

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Better than infecting mass humans with monkey DNA.

What a bizarre post!

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