Japan Today

U.S. team creates stem cells of 10 incurable diseases


U.S. scientists have cultivated a new line of stem cells that reproduce the genetic defects responsible for 10 incurable diseases such as muscular dystrophy and Parkinson's disease, a study said.

The team managed to convert ordinary skin and bone tissue cells from patients with these diseases into stem cells which contain the same genetic fault.

This could help step up research into finding an eventual cure, the study said in the latest edition of Cell magazine.

"Researchers have long wanted to find a way to move a patient's disease into the test tube, to develop cells that could be cultured into the many tissues relevant to diseases of the blood, the brain and the heart, for example," said investigator George Daley.

"Now, we have a way to do just that, to derive pluripotent cells from patients with disease, which means the cells can make any tissue and can grow forever.

"This enables us to model thousands of conditions using classical cell culture techniques."

Daley, from Children's Hospital Boston, worked with researchers from Harvard Medical School, Massachusetts General Hospital, and the University of Washington to create the disease-specific stem cell strains.

Such cells reproduce human illnesses more faithfully than those taken from animals such as mice.

Although the genetic differences between the two are small in some diseases, such as Down's Syndrome, the genetic fault does not trigger the same reaction in mice as in humans.

Other diseases which may be more closely studied thanks to this technique include juvenile onset diabetes; Huntington's disease; Down's syndrome and ADA-severe combined immunodeficiency, a form of the disorder commonly known as "boy-in-the-bubble disease."

© Wire reports

©2024 GPlusMedia Inc.

Login to comment

The skeptic in me sees this as a kind of bio-weapon development program, potentially at least.

0 ( +0 / -0 )

The team managed to convert ordinary skin and bone tissue cells from patients with these diseases into stem cells which contain the same genetic fault.-

Help me out here guys...converted one diseased skin and turned it into a diseased stem cell...and that's called progress??????

0 ( +0 / -0 )

OgieDoggie.....I'm assuming that now they can produce samples of the disease to run tests on without harming the people who give the samples. That means they can try more radical tests.

0 ( +0 / -0 )

Nice explanation SuperLib!

0 ( +0 / -0 )

Amazing. Dedication and expertise so profound they worked around the drastic and ethically troubling methods of using embryonic cells. Bush vindicated; the scientists win, America and the world wins.

"Kudos," as smithinjapan likes to say.

0 ( +0 / -0 )

SuperLib: I'm impressed! Nicely put, and I hope it is so.

Undecided: I do indeed like to say it, and I say it here.

0 ( +0 / -0 )

Login to leave a comment

Facebook users

Use your Facebook account to login or register with JapanToday. By doing so, you will also receive an email inviting you to receive our news alerts.

Facebook Connect

Login with your JapanToday account

User registration

Articles, Offers & Useful Resources

A mix of what's trending on our other sites