The discovery of antibiotics is one of the greatest medical breakthroughs of the 20th century. Before antibiotics, childbirth, a urinary tract infection, or a simple cut could lead to death from infection.
Antibiotics, a type of antimicrobial, have made many modern medical procedures possible, and now the global healthcare system relies on them.
Due to increasing antimicrobial use, microbes – such as bacteria, fungi and parasites – have developed the ability to resist the action of these medicines. The result is that common infections that were once easily treatable are becoming more difficult to cure and in some cases can be fatal.
Following the development of penicillin in the mid 1940s, many new classes of antibiotics were developed. However, since the 1980s there has been little investment into the development of new ones and very few have been approved.
There’s an urgent need for new antibiotics that work against drug-resistant bacteria. Drug-resistant infections are expected to claim more than 39 million lives between now and 2050 without further action.
So why are so few new antibiotics being successfully developed for medical use?
Investment in new drugs
Many pharmaceutical companies have left this area of research. On top of this, finding new and different types of antibiotics that will not be quickly rendered ineffective by existing antimicrobial resistance (AMR) is a formidable challenge.
Developing a new medicine is a complex, extremely expensive and time consuming endeavor. It can take 10 to 15 years from initial discovery all the way to approval, and costs more than $1 billion.
Most existing antibiotics are cheap and readily available. Any new antibiotics are generally considered “last resort” drugs, used only when all other treatment options have been exhausted. This is to prevent the development of resistance against them.
This means that the return on investment is much lower for antibiotics compared to medicines for many other illnesses.
Pharmaceutical companies are therefore unlikely to recover the costs associated with developing a new antibiotic at the end of a lengthy research process.
Testing what works safely
When searching for new potential antibiotics, researchers screen extracts and compound libraries and also use Artificial Intelligence (AI) approaches to look for those that show promising antimicrobial activity.
The scientists then refine and improve the initial findings in the lab by testing these against infection-causing pathogens. At the same time they make sure the compounds will not be harmful to humans.
For an antibiotic to work in a patient, it must reach the areas of the body where the illness-causing pathogen is located in high enough concentrations to clear the infection. At the same time it must minimise any side effects.
Scientists need to modify many parameters of molecules for safety and efficacy prior to undertaking the next stages of development.
After early-stage development, lead compounds must undergo a series of human clinical trials under carefully controlled conditions. This is to make sure that these are first and foremost safe and effective at treating the disease.
Recent developments
Universities and small companies are now responsible for much of the discovery and early-stage antibiotic development.
At the Ineos Oxford Institute for antimicrobial research we are developing new classes of antibiotics and new combination therapies.
In a combination therapy, two or more drugs are given to a patient at the same time, with each drug having a particular role.
One drug is the antibiotic, such as penicillin, and kills the bacteria.
The second drug targets the resistance mechanism that bacteria have evolved to evade the antibiotic and acts as an antibiotic guardian.
By targeting the resistance mechanism, the second drug protects the antibiotic from destruction and allows the antibiotic to clear the infection and cure the patient.
A recent potential combination therapy developed by us involved two guardian molecules being administered with one existing antibiotic. This triple combination showed promise against a broad range of drug-resistant bacteria.
Our work, however, cannot be done in isolation. Commitment from governments, the pharmaceutical industry and global public health bodies is required to support and sustain the antibiotic pipeline.
One strategy, in which the UK is a global leader, is to create a subscription-style model for purchasing antibiotics which is not linked to the number of antibiotics sold.
Healthcare providers would pay the pharmaceutical company a fixed fee for the antibiotics based on their usefulness, and not the amount used.
This separates demand from profit, making it more economically viable for companies to develop new antibiotics for global public health.
Alistair Farley is Science Lead, University of Oxford. Helen Smith is a Postdoctoral Research Associate, University of Oxford.
The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.
© The Conversation
11 Comments
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virusrex
The search for new drugs, specially antibiotic has become a very strong argument to support the right of developing countries to the organisms living in their territory, without a practical, strong economic benefit to incentivize these governments they could opt to let that biodiversity be lost for profitable development projects, which would mean that countless living things (that could hold the key for new antibiotics) would be lost as well.
mountainpear
@Virusrex I can work out what you are saying but punctuating your sentences would get your message across better!
virusrex
Thanks, cut 2/3 of the comments because I was rambling and it ended up badly constructed.
Zaphod
virusrex
Only 2/3?
Fossil
Progress is being made!!
Sven Asai
More interesting or important to recognize is the fact that the societies which have those expensive substances and the massive research, they are aging and shrinking anyway. While on contrary the societies that don't have it all as well as don't even know or want it, they grow, expand into all corners of the world and have ultra high birthrates. Now you have a corrected view on your super antibiotics and their usefulness, haven't you?
virusrex
So, nothing to say about the actual article then?
All societies have those expensive substances, only a few are shrinking and not for all this is in any way a problem.
Pretending developing countries don't have antibiotics (or even new antibiotics) is just not knowing what is actually available over the world, the "correction" you make is based on a false premise.
Fossil
No. I was clearly responding to the comment.
virusrex
Fortunately commenters here have no need to write according to the preferences of others.
Fossil
That's great. Some would call it free speech homey.
virusrex
Still perfectly great that people trying to make others write according to their personal preferences are ignored and there is nothing they can do about it.